Ndc 0173044200 20ml multidose vials singles storage. Primary objective of our study was to study efficacy of ondansetron by two different routes, i. Ondansetron is a well tolerated drug with few side effects. Dec 11, 2014 ondansetron 8 mg iv over 15 minutes caused a qtc prolongation of 5. Do not use in pets that are allergic to the medication. Doctors give trusted answers on uses, effects, sideeffects, and cautions.
Prevention of postoperative nausea andor vomiting 2. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Ondansetron is available under the following different brand names. Ondansetron tablets are well tolerated by patients over 65 years and no alteration of dosage, dosing frequency or route of administration are required. Oral, subcutaneous, and intravenous pharmacokinetics of. If a negative reaction occurs, please call your veterinary office. Ondansetron works by blocking one of the bodys natural substances that causes vomiting. Ondansetron 4 mg5 ml solution generic zofran o all. Ondansetron in treatment resistant obsessive compulsive. It can be given by mouth or by injection into a muscle or into a vein common side effects include diarrhea. Ondansetron is a selective 5ht3 receptor antagonist.
This study is the first largescale, doubleblind trial to demonstrate that ondansetron 8 mg bid for 3 days, a dosing regimen that may enhance patient convenience and compliance, is as effective as ondansetron 8 mg tid for 3 days in the prevention of nausea and vomiting associated with cyclophosphamidebased chemotherapy. Ondansetron injection, usp is a clear, colorless, nonpyrogenic, sterile solution. Serotonin receptors of the 5ht3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. Ondansetron has serious interactions with at least 119 different drugs. Dosage may be repeated twice, administered 4 and 8 hours after the initial dose. A healthcare provider will give you this injection. Ondansetron oral solution product monograph page 6 of 29 enzyme system of the liver.
Ondansetrons halflife is 3 to 6 hours at the maximum dose in chemotherapy patients of 32 mg daily. Ondansetron 2 mgml solution for injection summary of. The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Reproduction studies in rats and rabbits receiving oral ondansetron dosages up to 15 and 30 mgkg daily, respectively, and iv ondansetron dosages up to 4 mgkg daily approximately 1.
Generic drugs usually cost less than the brandname version. Uptodate, electronic clinical resource tool for physicians and patients that provides information on adult primary care and internal medicine, allergy and immunology, cardiovascular medicine, emergency medicine, endocrinology and diabetes, family medicine, gastroenterology and hepatology, hematology, infectious diseases, nephrology and. Multiday, single dose administration of 24 mg orally for hec has not been studied. Oral dosing can commence twelve hours later and may be continued for. If you have any further questions, ask your doctor or pharmacist. Ondansetron is a potent and highly selective serotonin 5ht3receptor antagonist which has demonstrated important antiemetic activity and good tolerability in the prevention of chemotherapyinduced nausea and vomiting. Zofran injection, 2 mgml is a clear, colorless, nonpyrogenic, sterile solution available as a 20ml multidose vial. Ondansetron is given by mouth or injection and is used off label in dogs and cats to treat vomiting. Doctors sometimes prescribe zofran to treat nausea and vomiting caused by cancer treatments. In june, 2012, the fda announced that ondansetron 32 mg iv single dose regimen is no longer. If you are taking this medication on a prescribed schedule, take it. Ondansetron, marketed under the brand name zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. Most people tolerate ondansetron well and, in many cases, side effects are minor and may be easily treated by you or your healthcare provider. Zofran ondansetron injection uses, side effects, dosage.
While ondansetrons mechanism of action has not been fully characterized, it is not a dopaminereceptor antagonist. Initially 16 mg, immediately before treatment over at least 15 minutes, followed by by intramuscular injection or by slow intravenous injection 8 mg every 4 hours if required for 2 doses, then by mouth 8 mg every 12 hours for up to 5 days, alternatively by rectum 16 mg daily for up to 5 days. Zofran injection should be diluted in 50 ml of 5% dextrose injection or 0. Feb 06, 2020 ondansetron is injected into a vein through an iv. Initially 8 mg, dose to be taken 12 hours before treatment, then 8 mg every 12 hours for up to 5 days. Learn how to use act ondansetron, and its dosage, warnings, sideeffects, and more. Ondansetron is a specific 5ht 3receptor antagonist which blocks 5ht 3 receptors in the gastrointestinal tract and in the cns. The disposition of ondansetron following oral, intramuscular im and intravenous iv dosing is similar with a steady state volume of distribution of about 140 l.
Not many clinicians are aware that ondansetron 4 to 8 mg iv should be administered over 2 to 5 min and certainly not as a bolus or in less than 30 s. The ondansetron dosing guidelines your healthcare provider will follow will vary depending on several factors, such as your age, medical conditions you are being treated for, and other medications you may be taking. You should not use ondansetron if you are also using apomorphine apokyn. Ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment ondansetron may be used for purposes not listed in this medication guide. Comparison of vestipitant with ondansetron for the treatment of. Ondansetron may also be used for vertigo or a spinning feeling in children with multiple sclerosis. Baxter data sheet 30 april 2019 page 2 of 9 baxter healthcare ltd carboplatin concentrations in the range 0. Both odt ondansetron 8 mg and iv ondansetron 4 mg are more effective than placebo for preventing spinal morphineinduced pruritus, but neither form of this agent reduces spinal morphineinduced postoperative nausea and vomiting in this patient group. No additional benefit was observed in patients who received intravenous ondansetron 8 mg. You should also tell your healthcare provider about any medications you are currently taking and any health conditions you may have, including liver problems, arrhythmia. Using dry hands, carefully remove from blister pack immediately before use. The ondansetron dosage will also vary depending on whether you are being treated for chemotherapy, radiation, or surgery. The recommended intravenous iv or intramuscular im dose of ondansetron is 8 mg administered as a slow injection in not less than 30.
Ondansetron is a carbazole derivative with antiemetic activity. Ondansetron has moderate interactions with at least 53 different drugs. Before taking ondansetron, be sure to talk to your healthcare provider about any warnings and precautions with ondansetron, such as drug interactions and allergic reactions. Dec 10, 2018 the adverse reactions in table 3 have been reported in.
Perhaps slow administration of ondansetron as recommended over 25 min would decrease the incidence of potentially lifethreatening adverse effects associated with ondansetron. To prevent nausea from chemotherapy, ondansetron is mixed in a solution and given by injection into a vein as directed by your doctor, usually over 15 minutes. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron. Zofran is a brand name for the drug ondansetron, prescribed to treat or prevent nausea and vomiting. Ondansetron is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment chemotherapy, radiation treatment, or drugs used to put you to sleep before surgery. Zofran injection fda prescribing information, side. Ondansetron can be given by oral, intravenous or intramuscular. Ondansetron may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished. Learn about the use and dosage of ondansetron zofran for dogs, includes important safety details and side effects. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. Po 8 mg 30 min before chemotherapy, then q8h times 2 more doses.
The dose depends on indication, childs age and weight. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. In the us, ondansetron ondansetron systemic is a member of the drug class 5ht3 receptor antagonists and is used to treat alcohol dependence, gastroenteritis, nauseavomiting, nauseavomiting chemotherapy induced, nauseavomiting postoperative, nauseavomiting radiation induced, obsessive compulsive disorder, postanesthetic shivering and pruritus. Ondansetron may be taken by mouth as tablets, syrup, or tabletsfilms that melt on.
Side effects are not common but include constipation, sleepiness, or head shaking. On the basis of available data no dosage adjustment is. Ondansetron doses were 8 mg and 32 mg infused intravenously iv over 15 min. Ondansetron is a 5ht 3 receptor antagonist that is an effective antiemetic in cats.
The ondansetron zofran controls most of my nauseavomiting, and i only get breakthrough symptoms of that when im in really bad shape. Equivalent systemic exposure is achieved after im and iv administration of ondansetron. The total daily dose must not exceed adult dose of 32 mg. Secondary objective was to study side effects of the study drugs.
Moderately emetogenic chemotherapy or radiotherapy. Ondansetron is completely and rapidly absorbed from the gastrointestinal tract after oral administration, and does not accumulate with. Six cats with normal complete blood count, serum biochemistry, and urinalysis received 2 mg oral mean 0. The recommended adult intravenous dosage of zofran is three 0.
Ondansetron is usually given just before your surgery begins, or within 2 hours after surgery. Of 527 surgical patients, 25% had breakthrough ponv and were equally randomized to one of six i. Comparative study of oral vs iv ondansetron for reducing. Oct 24, 2019 ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Doctors sometimes prescribe zofran to treat nausea and. Pharmacokinetics of three formulations of ondansetron hcl. Dose my pet is a website which can only stay online through ad revenue. While its mechanism of action has not been fully characterized, ondansetron is not a dopaminereceptor antagonist.
Ondansetron should be administered immediately before chemotherapy as a single intravenous dose of 0. Ondansetron comes as a tablet, a rapidly disintegrating dissolving tablet, and an oral solution liquid to take by mouth. When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy. Dec 31, 2019 in paediatric clinical studies, ondansetron was given by iv infusion diluted in 25 to 50 ml of saline or other compatible infusion fluid and infused over not less than 15 minutes. The recommended oral dose is 8mg to be taken twice daily. Dosage regimens of ondansetron tablets 8 mg twice daily and. Ondansetron solution for injection 2mg drug medication dosage.
Health professional information summary product information route of administration dosage form strength nonmedicinal ingredients oral tablets 4 mg and 8 mg ondansetron as hydrochloride. You may also hear ondansetron called by its brand name, zofran. Pantoprazole oral tablet is a prescription drug thats available as the brandname drug protonix. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5ht3 receptors, resulting in suppression of chemotherapy and radiotherapyinduced nausea and vomiting. To prevent nausea and vomiting caused by chemotherapy, ondansetron is given 30 minutes before the start of chemotherapy. Because ondansetron is metabolised by hepatic cytochrome p 450 drugmetabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the halflife of ondansetron. Ondansetron should start to work within 30 minutes to an hour. In june, 2012, the fda announced that ondansetron 32 mg iv single dose regimen is no longer indicated for chemotherapyinduced nauseavomiting cinv prophylaxis because of the risk of qt prolongation. Nov 18, 2019 the disposition of ondansetron following oral, intramuscular im and intravenous iv dosing is similar with a steady state volume of distribution of about 140 l. Ondansetron comes in lots of different forms and how it is given will depend on your individual circumstances. Act ondansetron tablet is used for nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, or nausea or vomiting occurring after a surgical procedure postoperative nauseavomiting. In the same trial, 56% of patients receiving a single 24 mg oral dose of ondansetron experienced no nausea during the 24hour trial period, compared with 36% of patients in the oral ondansetron 8 mg twiceaday group p 0. Ondansetron may be used for purposes not listed in this medication guide.
Postoperative nausea and vomiting adults for prevention of postoperative nausea and vomiting, the recommended oral dose is 16 mg given one hour prior to anaesthesia. Mar 20, 2020 at the 4mg dosage, 59% of patients receiving ondansetron versus 45% receiving placebo in the first trial p ondansetron versus 30% receiving placebo in the second trial p 0. Ondansetron is a highly specific and selective serotonin 5ht 3 receptor antagonist, with low affinity for dopamine receptors. The purpose of this study was to evaluate the pharmacokinetics of ondansetron in healthy cats. The absolute bioavailability and pharmacokinetics of three formulations of ondansetron hydrochloride 24 mg an oral tablet, an intravenous solution, and an extemporaneous rectal suppository. Ondansetron solution for injection 2mg drug medication dosage information. For child 6 months17 years body surface area up to 1. Zofran ondansetron side effects, dosage, interactions drugs. Zofran for dogs dose my pet dosage information for pet. Zofran injection ondansetron hydrochloride injection. The 5ht 3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema in the medulla. Data from clinical trials indicate that the drug ondansetron zofran increases the risk of a prolon. Side effects of ondansetron as with any medication, there are potential side effects of ondansetron, including headaches, fatigue, and constipation.
Ondansetron clinical pharmacokinetics springerlink. Ondansetron comes as a liquid, a tablet, an orally disintegrating tablet odt and an injection. Ondansetron tablet is used for nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, or nausea or vomiting occurring after a surgical procedure postoperative nauseavomiting. If you forget your dose, take it as soon as you remember. Zofran ondansetron side effects, dosage, interactions. Ondansetron 2 mgml solution for injection ondansetron read all of this leaflet carefully before you start using this medicine because it contains important information for you. Ondansetron 2 mgml solution for injection or infusion. Przofran tablets, oral solution and injection ondansetron hydrochloride dihydrate przofran odt oral disintegrating tablets ondansetron part i. Ondansetron comes as a solution liquid to be injected intravenously into a vein or intramuscularly into a muscle by a health care provider in a hospital or clinic. It has no effect on vomiting caused by motion sickness. You are free to browse adfree, but please consider supporting us by disabling your ad blocking software.
The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic. Two further intravenous doses may be given in 4hourly intervals. However, on the basis of available data, no dosage adjustment for ondansetron is recommended see precautions. But, if it is nearly time for your next dose, just take the next dose at the right time. May 02, 2020 this study was conducted to evaluate the efficacy of a single 8mg i. Weightbased dosing results in higher total daily doses compared to bsabased dosing see sections 4. Oral ondansetron 8 mg twice daily is as effective as 8 mg. Alternatively, a dose of 8mg of ondansetron may be administered by slow intravenous injection in not less than 30 seconds or intramuscular injection immediately.
532 1464 1071 600 709 1269 502 1516 552 1376 82 1597 985 11 1281 728 932 1163 595 247 161 568 992 370 560 381 134 371 535 217 1237 411 922 82 1022 855 543 728 1121 461