As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5ht3 receptors, resulting in suppression of chemotherapy and radiotherapyinduced nausea and vomiting. Ondansetron comes as a solution liquid to be injected intravenously into a vein or intramuscularly into a muscle by a health care provider in a hospital or clinic. Ondansetron should start to work within 30 minutes to an hour. Ondansetron is a well tolerated drug with few side effects. It can be given by mouth or by injection into a muscle or into a vein common side effects include diarrhea. The total daily dose must not exceed adult dose of 32 mg. Ondansetron is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment chemotherapy, radiation treatment, or drugs used to put you to sleep before surgery. Oct 24, 2019 ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.
Dec 31, 2019 in paediatric clinical studies, ondansetron was given by iv infusion diluted in 25 to 50 ml of saline or other compatible infusion fluid and infused over not less than 15 minutes. Dose my pet is a website which can only stay online through ad revenue. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Dosage regimens of ondansetron tablets 8 mg twice daily and. Doctors sometimes prescribe zofran to treat nausea and vomiting caused by cancer treatments. Ondansetron works by blocking one of the bodys natural substances that causes vomiting. But, if it is nearly time for your next dose, just take the next dose at the right time. Secondary objective was to study side effects of the study drugs. Ondansetron can be given by oral, intravenous or intramuscular. The 5ht 3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema in the medulla. You should not use ondansetron if you are also using apomorphine apokyn. The dose depends on indication, childs age and weight. Dec 11, 2014 ondansetron 8 mg iv over 15 minutes caused a qtc prolongation of 5.
Alternatively, a dose of 8mg of ondansetron may be administered by slow intravenous injection in not less than 30 seconds or intramuscular injection immediately. The ondansetron dosing guidelines your healthcare provider will follow will vary depending on several factors, such as your age, medical conditions you are being treated for, and other medications you may be taking. Ondansetron solution for injection 2mg drug medication dosage. Pharmacokinetics of three formulations of ondansetron hcl.
Two further intravenous doses may be given in 4hourly intervals. In june, 2012, the fda announced that ondansetron 32 mg iv single dose regimen is no longer indicated for chemotherapyinduced nauseavomiting cinv prophylaxis because of the risk of qt prolongation. Zofran ondansetron side effects, dosage, interactions drugs. Prevention of postoperative nausea andor vomiting 2. Ondansetron in treatment resistant obsessive compulsive. Both odt ondansetron 8 mg and iv ondansetron 4 mg are more effective than placebo for preventing spinal morphineinduced pruritus, but neither form of this agent reduces spinal morphineinduced postoperative nausea and vomiting in this patient group. If you are taking this medication on a prescribed schedule, take it. Oral ondansetron 8 mg twice daily is as effective as 8 mg. Pantoprazole oral tablet is a prescription drug thats available as the brandname drug protonix. The absolute bioavailability and pharmacokinetics of three formulations of ondansetron hydrochloride 24 mg an oral tablet, an intravenous solution, and an extemporaneous rectal suppository.
The recommended adult intravenous dosage of zofran is three 0. Initially 16 mg, immediately before treatment over at least 15 minutes, followed by by intramuscular injection or by slow intravenous injection 8 mg every 4 hours if required for 2 doses, then by mouth 8 mg every 12 hours for up to 5 days, alternatively by rectum 16 mg daily for up to 5 days. On the basis of available data no dosage adjustment is. Ondansetron is available under the following different brand names. In june, 2012, the fda announced that ondansetron 32 mg iv single dose regimen is no longer. Ondansetron doses were 8 mg and 32 mg infused intravenously iv over 15 min. Comparison of vestipitant with ondansetron for the treatment of. Ondansetron may be taken by mouth as tablets, syrup, or tabletsfilms that melt on. Primary objective of our study was to study efficacy of ondansetron by two different routes, i. Act ondansetron tablet is used for nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, or nausea or vomiting occurring after a surgical procedure postoperative nauseavomiting. Zofran for dogs dose my pet dosage information for pet. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron.
Ondansetron is a 5ht 3 receptor antagonist that is an effective antiemetic in cats. Ondansetron 2 mgml solution for injection ondansetron read all of this leaflet carefully before you start using this medicine because it contains important information for you. Equivalent systemic exposure is achieved after im and iv administration of ondansetron. Ndc 0173044200 20ml multidose vials singles storage. No additional benefit was observed in patients who received intravenous ondansetron 8 mg. Ondansetron is usually given just before your surgery begins, or within 2 hours after surgery. Ondansetron is a selective 5ht3 receptor antagonist. The ondansetron dosage will also vary depending on whether you are being treated for chemotherapy, radiation, or surgery. Ondansetron solution for injection 2mg drug medication dosage information. You are free to browse adfree, but please consider supporting us by disabling your ad blocking software. Zofran injection should be diluted in 50 ml of 5% dextrose injection or 0. Side effects are not common but include constipation, sleepiness, or head shaking. Mar 20, 2020 at the 4mg dosage, 59% of patients receiving ondansetron versus 45% receiving placebo in the first trial p ondansetron versus 30% receiving placebo in the second trial p 0.
In the same trial, 56% of patients receiving a single 24 mg oral dose of ondansetron experienced no nausea during the 24hour trial period, compared with 36% of patients in the oral ondansetron 8 mg twiceaday group p 0. Ondansetron is a highly specific and selective serotonin 5ht 3 receptor antagonist, with low affinity for dopamine receptors. Ondansetron is completely and rapidly absorbed from the gastrointestinal tract after oral administration, and does not accumulate with. This study is the first largescale, doubleblind trial to demonstrate that ondansetron 8 mg bid for 3 days, a dosing regimen that may enhance patient convenience and compliance, is as effective as ondansetron 8 mg tid for 3 days in the prevention of nausea and vomiting associated with cyclophosphamidebased chemotherapy. Doctors give trusted answers on uses, effects, sideeffects, and cautions.
Weightbased dosing results in higher total daily doses compared to bsabased dosing see sections 4. Ondansetron clinical pharmacokinetics springerlink. Ondansetron may be used for purposes not listed in this medication guide. Ondansetrons halflife is 3 to 6 hours at the maximum dose in chemotherapy patients of 32 mg daily. If a negative reaction occurs, please call your veterinary office.
The purpose of this study was to evaluate the pharmacokinetics of ondansetron in healthy cats. Uptodate, electronic clinical resource tool for physicians and patients that provides information on adult primary care and internal medicine, allergy and immunology, cardiovascular medicine, emergency medicine, endocrinology and diabetes, family medicine, gastroenterology and hepatology, hematology, infectious diseases, nephrology and. Of 527 surgical patients, 25% had breakthrough ponv and were equally randomized to one of six i. Generic drugs usually cost less than the brandname version. You should also tell your healthcare provider about any medications you are currently taking and any health conditions you may have, including liver problems, arrhythmia. Six cats with normal complete blood count, serum biochemistry, and urinalysis received 2 mg oral mean 0. Using dry hands, carefully remove from blister pack immediately before use. Dec 10, 2018 the adverse reactions in table 3 have been reported in. Health professional information summary product information route of administration dosage form strength nonmedicinal ingredients oral tablets 4 mg and 8 mg ondansetron as hydrochloride. To prevent nausea and vomiting caused by chemotherapy, ondansetron is given 30 minutes before the start of chemotherapy. Perhaps slow administration of ondansetron as recommended over 25 min would decrease the incidence of potentially lifethreatening adverse effects associated with ondansetron. In the us, ondansetron ondansetron systemic is a member of the drug class 5ht3 receptor antagonists and is used to treat alcohol dependence, gastroenteritis, nauseavomiting, nauseavomiting chemotherapy induced, nauseavomiting postoperative, nauseavomiting radiation induced, obsessive compulsive disorder, postanesthetic shivering and pruritus. Ondansetron tablets are well tolerated by patients over 65 years and no alteration of dosage, dosing frequency or route of administration are required.
Data from clinical trials indicate that the drug ondansetron zofran increases the risk of a prolon. While its mechanism of action has not been fully characterized, ondansetron is not a dopaminereceptor antagonist. Ondansetron tablet is used for nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, or nausea or vomiting occurring after a surgical procedure postoperative nauseavomiting. Serotonin receptors of the 5ht3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. Ondansetron is a potent and highly selective serotonin 5ht3receptor antagonist which has demonstrated important antiemetic activity and good tolerability in the prevention of chemotherapyinduced nausea and vomiting. Most people tolerate ondansetron well and, in many cases, side effects are minor and may be easily treated by you or your healthcare provider. Initially 8 mg, dose to be taken 12 hours before treatment, then 8 mg every 12 hours for up to 5 days. Ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment ondansetron may be used for purposes not listed in this medication guide. The recommended intravenous iv or intramuscular im dose of ondansetron is 8 mg administered as a slow injection in not less than 30. The recommended oral dose is 8mg to be taken twice daily. Ondansetron is a carbazole derivative with antiemetic activity.
Zofran is a brand name for the drug ondansetron, prescribed to treat or prevent nausea and vomiting. Ondansetron 2 mgml solution for injection summary of. Ondansetron comes as a tablet, a rapidly disintegrating dissolving tablet, and an oral solution liquid to take by mouth. Because ondansetron is metabolised by hepatic cytochrome p 450 drugmetabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the halflife of ondansetron. A healthcare provider will give you this injection. Ondansetron oral solution product monograph page 6 of 29 enzyme system of the liver. If you have any further questions, ask your doctor or pharmacist. However, on the basis of available data, no dosage adjustment for ondansetron is recommended see precautions. Baxter data sheet 30 april 2019 page 2 of 9 baxter healthcare ltd carboplatin concentrations in the range 0. May 02, 2020 this study was conducted to evaluate the efficacy of a single 8mg i. Ondansetron 4 mg5 ml solution generic zofran o all.
Ondansetron, marketed under the brand name zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. Ondansetron has moderate interactions with at least 53 different drugs. To prevent nausea from chemotherapy, ondansetron is mixed in a solution and given by injection into a vein as directed by your doctor, usually over 15 minutes. Zofran injection fda prescribing information, side. Learn about the use and dosage of ondansetron zofran for dogs, includes important safety details and side effects. Zofran injection, 2 mgml is a clear, colorless, nonpyrogenic, sterile solution available as a 20ml multidose vial.
If you forget your dose, take it as soon as you remember. Postoperative nausea and vomiting adults for prevention of postoperative nausea and vomiting, the recommended oral dose is 16 mg given one hour prior to anaesthesia. You may also hear ondansetron called by its brand name, zofran. Multiday, single dose administration of 24 mg orally for hec has not been studied. Ondansetron may also be used for vertigo or a spinning feeling in children with multiple sclerosis. Comparative study of oral vs iv ondansetron for reducing.
Dosage may be repeated twice, administered 4 and 8 hours after the initial dose. It has no effect on vomiting caused by motion sickness. Side effects of ondansetron as with any medication, there are potential side effects of ondansetron, including headaches, fatigue, and constipation. While ondansetrons mechanism of action has not been fully characterized, it is not a dopaminereceptor antagonist. Learn how to use act ondansetron, and its dosage, warnings, sideeffects, and more.
Do not use in pets that are allergic to the medication. Ondansetron injection, usp is a clear, colorless, nonpyrogenic, sterile solution. Przofran tablets, oral solution and injection ondansetron hydrochloride dihydrate przofran odt oral disintegrating tablets ondansetron part i. Ondansetron comes in lots of different forms and how it is given will depend on your individual circumstances. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. Ondansetron may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished. Zofran ondansetron side effects, dosage, interactions. Ondansetron comes as a liquid, a tablet, an orally disintegrating tablet odt and an injection. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Doctors sometimes prescribe zofran to treat nausea and. Ondansetron is given by mouth or injection and is used off label in dogs and cats to treat vomiting. The disposition of ondansetron following oral, intramuscular im and intravenous iv dosing is similar with a steady state volume of distribution of about 140 l.
Feb 06, 2020 ondansetron is injected into a vein through an iv. For child 6 months17 years body surface area up to 1. Zofran ondansetron injection uses, side effects, dosage. Not many clinicians are aware that ondansetron 4 to 8 mg iv should be administered over 2 to 5 min and certainly not as a bolus or in less than 30 s. Nov 18, 2019 the disposition of ondansetron following oral, intramuscular im and intravenous iv dosing is similar with a steady state volume of distribution of about 140 l.
Oral, subcutaneous, and intravenous pharmacokinetics of. Zofran injection ondansetron hydrochloride injection. The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic. Before taking ondansetron, be sure to talk to your healthcare provider about any warnings and precautions with ondansetron, such as drug interactions and allergic reactions. The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Ondansetron should be administered immediately before chemotherapy as a single intravenous dose of 0. Po 8 mg 30 min before chemotherapy, then q8h times 2 more doses.
Oral dosing can commence twelve hours later and may be continued for. Ondansetron 2 mgml solution for injection or infusion. When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy. Moderately emetogenic chemotherapy or radiotherapy. The ondansetron zofran controls most of my nauseavomiting, and i only get breakthrough symptoms of that when im in really bad shape. Ondansetron has serious interactions with at least 119 different drugs. Fourteen patients with a dsm iv diagnosis of treatment resistant ocd, under stable treatment with ssris and neuroleptic augmentation will enter an 12week single blind trial of ondansetron initiated at a dose of 0. Reproduction studies in rats and rabbits receiving oral ondansetron dosages up to 15 and 30 mgkg daily, respectively, and iv ondansetron dosages up to 4 mgkg daily approximately 1.
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